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Improved General and Height-Specific Quality of Life in Children With Short Stature After 1 Year on Growth Hormone

Laura G González Briceño1,2, Magali Viaud1,3, Jacques Beltrand1,3,4

  • 1Pediatric Endocrinology, Diabetology and Gynecology Department, Hôpital Universitaire Necker-Enfants Malades [Assistance Publique Hôpitaux de Paris (AP-HP)], Paris, France.

The Journal of Clinical Endocrinology and Metabolism
|January 17, 2019
PubMed

Insights

Growth hormone (GH) treatment significantly improved children's emotional and social quality of life (QoL) after one year. Height gains correlated positively with QoL improvements, benefiting children with short stature.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Quality of Life Research

Background:

  • Short stature in children can cause psychosocial distress and negatively impact quality of life (QoL).
  • Growth hormone (GH) therapy is a potential intervention to normalize height and improve QoL.

Purpose of the Study:

  • To evaluate general and height-specific QoL in children and adolescents with short stature after one year of GH treatment.

Main Methods:

  • A prospective, single-center observational cohort study included 74 children (aged ≥ 4 years) treated with GH.
  • Patients completed general (PedsQL 4.0) and height-specific (QoLiSSY) QoL questionnaires at baseline and after one year.
  • Correlations between height gain and QoL improvements were analyzed.

Main Results:

  • GH treatment led to significant improvements in self-reported emotional and social QoL.
  • Parent-reported QoL also showed significant improvements in physical, emotional, and social domains.
  • Height standard deviation score (SDS) gains positively correlated with QoL improvements from both self and parent reports.

Conclusions:

  • One year of GH treatment significantly enhances emotional and social QoL in children with short stature.
  • Both general and height-specific QoL measures indicate positive outcomes.
  • The degree of height gain is associated with the extent of QoL improvement.
Abstract

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