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Characterizing the Intraoperative Microelectrode Recording-Induced Microlesion Effect on Motor Symptoms in Patients
Dursun Aygun1, Umit Akin Dere, Onur Yildiz
1Ondokuz Mayis University, Department of Neurology, Samsun, Turkey.
Aim:
To investigate microelectrode recording (MER)-induced microlesion effect (MLE) on the motor symptoms of 30 patients with Parkinson’s disease (PD) who underwent deep brain stimulation of the subthalamic nucleus.
Material And Methods:
MER-induced MLE was evaluated based on the difference between tremor, rigidity, and bradykinesia scores in the preoperative off-state and intraoperative state following MER and before test stimulation.
Results:
MLE scores improved by 21.7% [left (L) side] and by 13.6% [right (R) side] from baseline (p < 0.05). Tremor scores improved by 31.5% (L) and by 14.2% (R) (p < 0.05), rigidity scores improved by 17.3% (L) and by 14.2% (R) (p < 0.05) and bradykinesia scores improved by 20.6% (L) and by 11.5% (R) (p < 0.05) from baseline. There was no significant difference between MLE and the number of microelectrodes used (p > 0.05).
Conclusion:
MER-induced MLE improved motor symptoms and was not correlated with the number of microelectrodes used during the procedure.
Insights
Microelectrode recording (MER)-induced microlesion effect (MLE) significantly improved motor symptoms in Parkinson's disease patients undergoing subthalamic nucleus deep brain stimulation. The improvements were not linked to the number of microelectrodes used.
Area of Science:
- Neurosurgery
- Neurology
- Movement Disorders
Background:
- Parkinson's disease (PD) is a progressive neurodegenerative disorder affecting motor function.
- Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a key treatment for advanced PD.
- Microelectrode recording (MER) is crucial for precise electrode placement during STN-DBS.
Purpose of the Study:
- To evaluate the impact of MER-induced microlesion effect (MLE) on motor symptoms in PD patients.
- To determine if the extent of MLE correlates with the number of microelectrodes utilized.
Main Methods:
- The study involved 30 PD patients undergoing STN-DBS.
- MER-induced MLE was assessed by comparing motor symptom scores (tremor, rigidity, bradykinesia) preoperatively and intraoperatively after MER.
- Scores were analyzed before test stimulation.
Main Results:
- Significant improvements in motor symptoms were observed post-MER (p < 0.05).
- Left-sided improvements: 21.7% for MLE, 31.5% for tremor, 17.3% for rigidity, 20.6% for bradykinesia.
- Right-sided improvements: 13.6% for MLE, 14.2% for tremor, 14.2% for rigidity, 11.5% for bradykinesia.
- No significant correlation was found between MLE and the number of microelectrodes used (p > 0.05).
Conclusions:
- MER-induced MLE offers a therapeutic benefit by improving motor symptoms in PD patients.
- The positive effects of MLE are independent of the number of microelectrodes employed during the MER procedure.