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Database-guided Flow-cytometry for Evaluation of Bone Marrow Myeloid Cell Maturation

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The Myeloid Cell Compartment-Cell by Cell.

Kevin Bassler¹, Jonas Schulte-Schrepping¹, Stefanie Warnat-Herresthal¹

¹Department for Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn, 53115 Bonn, Germany; email: s6kebass@uni-bonn.de , s6jsschu@uni-bonn.de , stefanie.herresthal@uni-bonn.de , a.aschenbrenner@uni-bonn.de , j.schultze@uni-bonn.de.

Annual Review of Immunology

|January 17, 2019

Summary

Single-cell RNA sequencing is revolutionizing our understanding of myeloid cell heterogeneity. These advanced techniques reveal continuous developmental paths and novel subsets, crucial for comprehending immune cell function in health and disease.

Keywords:

dendritic cells macrophages monocytes myeloid cells single-cell RNA sequencing single-cell analysis

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Published on: March 11, 2016

Area of Science:

Immunology
Cell Biology
Genomics

Background:

Myeloid cells (monocytes, dendritic cells, macrophages, granulocytes) are key immune components.
Recent findings challenge traditional models of myeloid cell development and activation.
Their plasticity and heterogeneity in health and disease remain poorly understood.

Purpose of the Study:

To explore the impact of single-cell genomics on myeloid cell research.
To revise existing models of myeloid cell ontogeny and subset classification.
To outline future directions for understanding myeloid cell complexity.

Main Methods:

Analysis of single-cell RNA sequencing (scRNA-seq) data.
Revisiting established models of hematopoiesis and myeloid cell differentiation.
Leveraging data from large-scale projects like the Human Cell Atlas.

Main Results:

scRNA-seq data challenges discrete hematopoietic intermediates, suggesting continuous myeloid trajectories.
Unbiased genomic analysis necessitates revising cell subset definitions based on protein markers.
Novel tissue macrophage subsets have been identified, highlighting greater heterogeneity.

Conclusions:

Single-cell genomics offers unprecedented resolution into myeloid cell heterogeneity.
Understanding myeloid cell plasticity is critical for both homeostasis and inflammatory conditions.
Further research is needed to fully elucidate the myeloid compartment's role in health and disease.