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[Effect of Dengzhan Xxin Injection Dosage on Renal function Using Propensity Score Estimation].

Yuan-Yuan Li, Hao Tang, Lin Li

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    Summary
    This summary is machine-generated.

    Dengzhan Xixin Injection (DZI) use exceeding recommended dosage did not significantly alter renal function. This study found no abnormal changes in serum creatinine (SCr) or blood urea nitrogen (BUN) levels in patients receiving higher DZI doses.

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    Area of Science:

    • Pharmacology
    • Nephrology
    • Clinical Medicine

    Background:

    • Dengzhan Xixin Injection (DZI) is a widely used medication.
    • Understanding the impact of DZI dosage on renal function is crucial for patient safety.
    • Previous studies have not comprehensively evaluated high-dose DZI effects on renal indices.

    Purpose of the Study:

    • To investigate the clinical effects of Dengzhan Xixin Injection (DZI) dosage on renal function.
    • To analyze the relationship between DZI administration and abnormal changes in serum creatinine (SCr) and blood urea nitrogen (BUN).

    Main Methods:

    • Retrospective analysis of 21,498 patient records from 20 Chinese hospital information system (HIS) databases.
    • Inclusion of 13,696 patients aged 18-80, divided into ultra-dose (>40 mL) and conventional-dose (≤40 mL) groups.
    • Comparison of SCr and BUN levels 7 days before and after DZI administration using stratified analysis and propensity score estimation to control for 71 confounding factors.

    Main Results:

    • No significant differences in baseline characteristics (age, gender, admission condition, DZI course) between the ultra-dose and conventional-dose groups.
    • Propensity score estimation revealed no statistically significant difference in the changes of abnormal renal functions between the two groups after balancing confounders.
    • Specifically, changes in SCr and BUN levels did not differ significantly between patients receiving ultra-doses versus conventional doses of DZI.

    Conclusions:

    • Clinical use of Dengzhan Xixin Injection (DZI) at dosages exceeding the recommended amount did not lead to abnormal changes in renal function based on HIS data analysis.
    • The findings suggest that exceeding the recommended DZI dosage is not associated with adverse renal outcomes in the studied patient population.
    • Further prospective studies may be warranted to confirm these findings in diverse clinical settings.