[Effect of Dengzhan Xxin Injection Dosage on Renal function Using Propensity Score Estimation]

Area of Science:

• Pharmacology
• Nephrology
• Clinical Medicine

Background:

• Dengzhan Xixin Injection (DZI) is a widely used medication.
• Understanding the impact of DZI dosage on renal function is crucial for patient safety.
• Previous studies have not comprehensively evaluated high-dose DZI effects on renal indices.

Purpose of the Study:

• To investigate the clinical effects of Dengzhan Xixin Injection (DZI) dosage on renal function.
• To analyze the relationship between DZI administration and abnormal changes in serum creatinine (SCr) and blood urea nitrogen (BUN).

Main Methods:

• Retrospective analysis of 21,498 patient records from 20 Chinese hospital information system (HIS) databases.
• Inclusion of 13,696 patients aged 18-80, divided into ultra-dose (>40 mL) and conventional-dose (≤40 mL) groups.
• Comparison of SCr and BUN levels 7 days before and after DZI administration using stratified analysis and propensity score estimation to control for 71 confounding factors.

Main Results:

• No significant differences in baseline characteristics (age, gender, admission condition, DZI course) between the ultra-dose and conventional-dose groups.
• Propensity score estimation revealed no statistically significant difference in the changes of abnormal renal functions between the two groups after balancing confounders.
• Specifically, changes in SCr and BUN levels did not differ significantly between patients receiving ultra-doses versus conventional doses of DZI.

Conclusions:

• Clinical use of Dengzhan Xixin Injection (DZI) at dosages exceeding the recommended amount did not lead to abnormal changes in renal function based on HIS data analysis.
• The findings suggest that exceeding the recommended DZI dosage is not associated with adverse renal outcomes in the studied patient population.
• Further prospective studies may be warranted to confirm these findings in diverse clinical settings.