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Resistin: A reappraisal.

E Acquarone1, F Monacelli1, R Borghi1

  • 1DIMi, Department of Internal Medicine and medical specialties, Viale Benedetto XV, 6, 16132 University of Genoa, Genoa, Italy.

Mechanisms of Ageing and Development
|January 17, 2019
PubMed
Summary
This summary is machine-generated.

Aging involves declining stress response and homeostasis. Resistin, a key adipokine, links aging to chronic diseases by affecting metabolism and inflammation.

Keywords:
AdipokinesAgingAlzheimer’s diseaseMetabolismResistin

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Area of Science:

  • Gerontology and metabolic research
  • Molecular biology of aging

Background:

  • Aging is characterized by reduced organismal resilience to stress and homeostatic imbalance.
  • Changes in adipokine expression during aging are implicated in chronic diseases and frailty.
  • Resistin, an adipokine, has emerged as a significant factor in the aging process.

Purpose of the Study:

  • To review the role of resistin as a molecular link between aging and age-related conditions.
  • To discuss the clinical implications of resistin's involvement in aging.

Main Methods:

  • Literature review focusing on resistin's function in aging.
  • Analysis of resistin's impact on metabolic and inflammatory pathways.
  • Examination of resistin's association with age-related diseases.

Main Results:

  • Resistin regulates glucose metabolism and impacts insulin sensitivity.
  • Elevated resistin levels are associated with insulin resistance and inflammation.
  • Resistin plays a crucial role in metabolic, inflammatory, and autoimmune diseases.

Conclusions:

  • Resistin acts as a molecular mediator connecting aging processes with age-related pathologies.
  • Understanding resistin's role offers potential therapeutic targets for age-related conditions.