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Updated: Jan 30, 2026

Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters
Published on: June 23, 2023
Gaining Weight: Insulin-Eating Islet Macrophages
Olga Spadaro1, Vishwa Deep Dixit1
1Department of Comparative Medicine and Yale Center for Research on Aging, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA.
Abstract:
The role of the immune system in homeostasis of pancreatic β cells in type 2 diabetes mellitus is poorly characterized. In a recent issue of Cell Metabolism, Ying et al. (2018) report that two subpopulations of macrophages expand during obesity to impair β cell function.
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