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Detection of Small GTPase Prenylation and GTP Binding Using Membrane Fractionation and GTPase-linked Immunosorbent Assay
Published on: November 11, 2018
Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata
Bao-Jun Zhang1,2,3, Wen-Wei Fu1,2, Rong Wu1,2
1School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Abstract:
Six new prenylated xanthones (1: -6: ) and seventeen known xanthones were isolated from extracts of Garcinia bracteata leaves. Their structures were determined by extensive NMR and MS spectroscopic data analysis. The inhibitory activities of the isolates were assayed on HeLa, A549, PC-3, HT-29, and WPMY-1 cell lines. Compounds 1: and 15: -17: showed moderate inhibitory effects on tumor cell growth, with IC50s ranging from 3.7 to 14.7 µM.
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