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[Treating Moderately Severe Acute Pancreatitis with Raw Rhubarbs by Intranasal Jejuna Injection: a Randomized

Li-Xin Yang, Jing Liu, Yun Xing

    Zhongguo Zhong Xi Yi Jie He Za Zhi Zhongguo Zhongxiyi Jiehe Zazhi = Chinese Journal of Integrated Traditional and Western Medicine
    |January 17, 2019
    PubMed

    Insights

    Raw rhubarb administered via intranasal jejunal injection effectively improved gastrointestinal function and coagulation-fibrinolysis in patients with moderately severe acute pancreatitis. This treatment accelerated recovery and reduced complications, enhancing patient outcomes.

    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Internal Medicine

    Background:

    • Moderately severe acute pancreatitis (MSAP) presents significant clinical challenges.
    • Optimizing gastrointestinal recovery and managing coagulation abnormalities are crucial in MSAP management.

    Purpose of the Study:

    • To evaluate the clinical efficacy of raw rhubarb administered via intranasal jejunal injection for MSAP.
    • To assess the impact of raw rhubarb on gastrointestinal function and the coagulation-fibrinolysis system in MSAP patients.

    Main Methods:

    • Eighty-four MSAP patients were randomized into control and treatment groups.
    • The treatment group received routine care plus intranasal jejunal raw rhubarb (100 mL, twice daily for 3-7 days).
    • Gastrointestinal recovery markers and coagulation parameters (PT, APTT, TT, Fib, PLT, DD, Protein C) were monitored.

    Main Results:

    • Intranasal jejunal raw rhubarb significantly shortened the time to gas passage, bowel sound recovery, distension disappearance, and abdominal pain resolution.
    • Treatment with raw rhubarb led to improvements in coagulation-fibrinolysis markers, including decreased PT, APTT, Fib, TT, and DD, and increased Protein C.
    • The incidence of complications was lower, and the cure rate was higher in the raw rhubarb treatment group compared to the control group.

    Conclusions:

    • Intranasal jejunal administration of raw rhubarb is a viable therapeutic option for moderately severe acute pancreatitis.
    • This approach effectively ameliorates gastrointestinal symptoms and positively modulates the coagulation-fibrinolysis system in MSAP patients.
    • Raw rhubarb treatment demonstrates potential in reducing complications and improving recovery rates in MSAP.

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