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[Correlation Research on HGF and c-Met of Chronic Erosive Gastritis Patients]
Insights
Hepatocyte growth factor (HGF) and its receptor (c-Met) levels are elevated in patients with chronic erosive gastritis, particularly in the turbidity toxin intrinsic syndrome group. These factors correlate significantly with disease severity.
Area of Science:
- Gastroenterology
- Molecular Biology
- Biochemistry
Background:
- Chronic erosive gastritis is a common gastrointestinal disorder.
- Hepatocyte growth factor (HGF) and its receptor (c-Met) play crucial roles in tissue repair and regeneration.
- Understanding the role of HGF/c-Met in gastritis may offer therapeutic insights.
Purpose of the Study:
- To investigate the correlation between HGF and c-Met in serum and gastric mucosa tissues.
- To compare HGF and c-Met expression levels in different syndrome groups of chronic erosive gastritis.
- To explore the relationship between HGF/c-Met and disease presentation in chronic erosive gastritis.
Main Methods:
- Seventy patients with chronic erosive gastritis were categorized into turbidity toxin intrinsic syndrome and Gan-wei disharmony syndrome groups.
- HGF levels in serum and HGF/c-Met levels in gastric mucosa tissues were quantified.
- Statistical analyses were performed to determine correlations between HGF and c-Met in tissues, and between serum HGF and tissue HGF.
Main Results:
- HGF and c-Met expression levels were significantly higher in the turbidity toxin intrinsic syndrome group compared to the Gan-wei disharmony syndrome group (P < 0.05).
- A strong positive correlation was observed between HGF and c-Met expression in gastric mucosa tissues (r = 0.831, P < 0.05).
- Serum HGF levels showed a significant positive correlation with HGF levels in gastric mucosa tissues (r = 0.656, P < 0.05).
Conclusions:
- The expression levels of HGF and c-Met are correlated with turbidity toxin intrinsic syndrome in patients with chronic erosive gastritis.
- HGF and c-Met may serve as potential biomarkers for assessing the severity and specific subtypes of chronic erosive gastritis.
Abstract:
Objective To observe the correlation of hepatocyte growth factor (HGF) and Hepato- cyte growth factor receptor (c-Met ) in serum and gastric mucosa tissues of chronic erosive gastritis pa- tients. Methods Totally 70 patients with chronic erosive gastritis were selected and assigned to turbidity toxin intrinsic syndrome group and Gan-wei disharmony syndrome group, HGF expression level of ser- um,and HGF,c-Met expression level of gastric mucosa tissues were measured;the correlation of HGF and c-Met in gastric mucosa tissues, and the correlation of HGF in serum and gastric mucosa tissues were analyzed. Results The expression level of HGF and c-Met in turbidity toxin intrinsic syndrome group was higher than that in Gan-wei disharmony syndrome group (P <0. 05) ; the expression level of HGF in gastric mucosa tissues was positively correlated with c-Met(r =0. 831 , P <0. 05) ; the expression level of HGF in serum was positively correlated with that of gastric mucosa tissues(r =0. 656, P <0. 05). Conclusions There was correlation between turbidity toxin intrinsic syndrome of Chronic Erosive Gastri- tis patients and the expression level of HGF and c-Met.
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