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Updated: Jan 30, 2026

Heat-Induced Antigen Retrieval: An Effective Method to Detect and Identify Progenitor Cell Types during Adult Hippocampal Neurogenesis
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Ascorbic Acid Mitigates D-galactose-Induced Brain Aging by Increasing Hippocampal Neurogenesis and Improving Memory

Sung Min Nam1, Misun Seo2, Jin-Seok Seo3

  • 1Department of Anatomy, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea. skavet@konkuk.ac.kr.

Nutrients
|January 18, 2019
PubMed
Summary

Ascorbic acid supplementation prevented D-galactose-induced brain aging in mice. It improved neurogenesis, synaptic plasticity, and memory, offering potential as a dietary supplement for adult brain health.

Keywords:
D-galactoseascorbic acidbrain aginghippocampusneurogenesis

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Gerontology

Background:

  • Ascorbic acid is vital for brain development and homeostasis.
  • The impact of ascorbic acid on adult brain aging remains unclear.
  • D-galactose (D-gal) induces brain aging via oxidative stress.

Purpose of the Study:

  • To investigate the effect of ascorbic acid on D-galactose-induced brain aging.
  • To determine if ascorbic acid can prevent cognitive decline and neurogenesis reduction.

Main Methods:

  • Mice received D-galactose for 10 weeks, with ascorbic acid co-administered for the final 4 weeks.
  • Assessed hippocampal neurogenesis, cognitive function, synaptic plasticity markers, and oxidative/inflammatory markers.
  • Analyzed expression of key proteins including superoxide dismutase, sirtuin1, and neurotrophic factors.

Main Results:

  • Ascorbic acid prevented D-gal-induced reduction in hippocampal neurogenesis and cognitive function.
  • It preserved synaptic plasticity markers (synaptophysin, pCaMKII) and normalized antioxidant/anti-inflammatory pathways.
  • Restored levels of superoxide dismutase, sirtuin1, caveolin-1, and brain-derived neurotrophic factor, while reducing inflammatory markers.

Conclusions:

  • Ascorbic acid ameliorates D-galactose-induced brain aging through antioxidant and anti-inflammatory mechanisms.
  • It enhances hippocampus-dependent memory function.
  • Ascorbic acid shows potential as a dietary supplement to combat adult brain aging.