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A Direct, Early Stage Guanidinylation Protocol for the Synthesis of Complex Aminoguanidine-containing Natural Products
Published on: September 9, 2016
Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies
Dik-Lung Ma1, Chun Wu2, Sha-Sha Cheng3
1Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong 999077, China. edmondma@hkbu.edu.hk.
Abstract:
Platinum-based drugs have revolutionized cancer care, but are unfortunately associated with various adverse effects. Meanwhile, natural product scaffolds exhibit multifarious bioactivities and serve as an attractive resource for cancer therapy development. Thus, the conjugation of natural product scaffolds to metal complexes becomes an attractive strategy to reduce the severe side effects arising from the use of metal bearing drugs. This review aims to highlight the recent examples of natural product-conjugated metal complexes as cancer therapies with enhanced selectivity and efficacy. We discuss the mechanisms and features of different conjugate complexes and present an outlook and perspective for the future of this field.
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