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The emerging role of WISP proteins in tumorigenesis and cancer therapy

Yi Liu1, Yizuo Song1, Miaomiao Ye1

  • 1Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Wenzhou Medical University, No. 109 Xueyuan Xi Road, Wenzhou, 325027, Zhejiang, China.

Journal of Translational Medicine
|January 18, 2019
PubMed

Insights

WNT1 inducible signaling pathway proteins (WISP) are crucial in various cancers, influencing cell growth, death, and spread. Targeting WISP proteins offers a promising new strategy for effective cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • WNT1 inducible signaling pathway proteins (WISP) are part of the CCN growth factor family.
  • WISP proteins (WISP1-3) are implicated in the development and progression of numerous human cancers.
  • WISP proteins play diverse roles in malignancies, affecting key cellular processes.

Purpose of the Study:

  • To review the physiological functions of WISP proteins across various human cancers.
  • To elucidate the role of WISP proteins in tumorigenesis and cancer progression.
  • To explore the therapeutic potential of targeting WISP proteins in cancer treatment.

Main Methods:

  • Literature review of existing studies on WISP proteins in cancer.
  • Analysis of the involvement of WISP proteins in cancer development and progression.
  • Discussion of WISP protein's role in cell proliferation, apoptosis, invasion, and metastasis.

Main Results:

  • WISP proteins are significantly involved in the tumorigenesis and progression of a wide range of human cancers.
  • WISP proteins exhibit distinct biological functions in different types of malignancies.
  • Evidence suggests WISP proteins are critical regulators of cancer cell proliferation, apoptosis, invasion, and metastasis.

Conclusions:

  • WISP proteins are key players in cancer development and progression.
  • Targeting WISP proteins represents a potential therapeutic strategy for human cancers.
  • Modulating WISP protein activity could lead to improved cancer patient treatments.
Keywords:
CancerDrugOncogeneTargetsTherapyWISP

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