Related Experiment Video

Updated: Jan 30, 2026

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
10:35

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses

Published on: November 28, 2010

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Apatinib exerts anti-tumour effects on ovarian cancer cells

Jing Ding1, Xiao-Yan Cheng2, Shuang Liu1

  • 1Department of Gynecology, Harbin Medical University Cancer Hospital, No. 150 Haping Road, Nangang District, Harbin 150040, Heilongjiang Province, China.

Gynecologic Oncology
|January 18, 2019
PubMed
Abstract

Insights

Apatinib inhibits ovarian cancer cell migration and in vivo tumor growth by suppressing key signaling pathways. This orally active agent shows potential as an anti-angiogenic therapy for ovarian cancer.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Apatinib, a VEGFR-2 inhibitor, demonstrates anti-tumor effects.
  • The role of apatinib in ovarian cancer is not well-defined.

Purpose of the Study:

  • Investigate apatinib's effects on ovarian cancer cells in vitro and in vivo.
  • Elucidate the mechanisms underlying apatinib's action in ovarian cancer.

Main Methods:

  • Assessed cell viability, migration, and invasion.
  • Analyzed cell cycle and apoptosis via flow cytometry.
  • Utilized Western blotting for signaling pathway analysis and a mouse xenograft model for in vivo efficacy.

Main Results:

  • Apatinib inhibited ovarian cancer cell migration but not proliferation.
  • Suppressed epithelial-mesenchymal transition by inhibiting JAK/STAT3, PI3K/AKT, and Notch pathways.
  • Demonstrated significant tumor growth inhibition in vivo.

Conclusions:

  • Apatinib is a potent, orally active anti-angiogenic agent.
  • Shows significant potential as an anti-ovarian cancer therapeutic.
Keywords:
ApatinibCell migrationEpithelial-mesenchymal transitionOvarian cancerSignalling pathway

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