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Phage Therapy in the Postantibiotic Era.

Fernando L Gordillo Altamirano1, Jeremy J Barr1

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Bacteriophage therapy offers a promising solution to the growing antibiotic resistance crisis. This review explores phage therapy

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Biotechnology

Background:

  • Antibiotic resistance poses a significant global health threat, making infections difficult to treat.
  • Bacteriophages (phages), viruses that infect bacteria, present a viable alternative to antibiotics.
  • Phage therapy, historically significant, is regaining prominence due to rising antimicrobial resistance.

Purpose of the Study:

  • To provide a forward-looking perspective on phage therapy's role in combating antibiotic resistance.
  • To review the biological principles, evolutionary aspects, and clinical applications of phage therapy.
  • To explore novel strategies and benefits of phage therapy beyond clinical use.

Main Methods:

  • Review of existing literature, including recent reports and human clinical trials.
  • Analysis of biological and evolutionary principles governing phage-bacteria interactions.
  • Examination of conventional and innovative phage therapy approaches.

Main Results:

  • Phage therapy is a versatile approach with potential applications in treating resistant infections.
  • Novel strategies like phage-antibiotic combinations and bioengineered phages show promise.
  • Phage therapy offers benefits beyond clinical applications, including educational and economic opportunities.

Conclusions:

  • Phage therapy is a crucial component in multidimensional strategies against antibiotic resistance.
  • The review highlights the versatility and potential of phage therapy as an alternative to antibiotics.
  • Phage therapy presents opportunities for scientific outreach, interdisciplinary collaboration, and innovation.