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Updated: Jan 30, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
Treating Polymicrobial Infections in Chronic Diabetic Wounds
Pranali J Buch1, Yunrong Chai2, Edgar D Goluch3,2
1Department of Chemical Engineering, Northeastern University, Boston, Massachusetts, USA.
Abstract:
This review provides a comprehensive summary of issues associated with treating polyclonal bacterial biofilms in chronic diabetic wounds. We use this as a foundation and discuss the alternatives to conventional antibiotics and the emerging need for suitable drug delivery systems. In recent years, extraordinary advances have been made in the field of nanoparticle synthesis and packaging. However, these systems have not been incorporated into the clinic for treatments other than for cancer or severe genetic diseases. We present a unifying perspective on how the field is evolving and the need for an early amalgamation of engineering principles and a biological understanding of underlying phenomena in order to develop a therapy that is translatable to the clinic in a shorter time.
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