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Correlation analysis between 25-hydroxyvitamin D3, vitamin B12 and vitamin C and endothelial function of patients

Xiaoming Qin1, Lei Qin2, Jiachen Luo1

  • 1Department of Cardiology, Shanghai Tenth People's Hospital, Tenth People's Hospital of Tongji University, Shanghai 200072, P.R. China.

Experimental and Therapeutic Medicine
|January 18, 2019
PubMed

Insights

Low levels of 25-hydroxyvitamin D3, vitamin B12, and vitamin C are linked to endothelial dysfunction in coronary heart disease (CHD) patients. These vitamins, along with hypertension and BMI, predict the severity of vascular issues in CHD.

Area of Science:

  • Cardiovascular Medicine
  • Nutritional Science
  • Biochemistry

Background:

  • Coronary heart disease (CHD) is a significant global health concern.
  • Endothelial dysfunction plays a critical role in the pathogenesis of CHD.
  • The influence of specific vitamin levels on endothelial function in CHD patients requires further investigation.

Purpose of the Study:

  • To investigate the correlation between serum levels of 25-hydroxyvitamin D3, vitamin B12, and vitamin C and endothelial function in patients with coronary heart disease.
  • To assess the predictive value of these vitamins, hypertension, and body mass index (BMI) for coronary endothelial dysfunction.

Main Methods:

  • A case-control study involving 40 CHD patients and 45 healthy controls.
  • Measurement of serum biochemical indicators, including 25-hydroxyvitamin D3, vitamin B12, vitamin C, homocysteine (Hcy), nitric oxide (NO), and endothelial NOS (eNOS).
  • Assessment of arterial lesions via coronary angiography and correlation analysis.

Main Results:

  • CHD patients exhibited significantly higher rates of hypertension and BMI compared to controls.
  • Lower serum levels of 25-hydroxyvitamin D3, vitamin B12, and vitamin C were observed in CHD patients.
  • CHD patients showed increased incidence of double- and triple-branch arterial lesions and higher Hcy levels, with lower NO and eNOS levels.
  • 25-hydroxyvitamin D3, vitamin B12, and vitamin C were negatively correlated with serum NO levels.
  • Hypertension, BMI, 25-hydroxyvitamin D3, vitamin B12, and C demonstrated independent predictive value for coronary endothelial dysfunction.

Conclusions:

  • Serum levels of 25-hydroxyvitamin D3, vitamin B12, and vitamin C are closely associated with vascular endothelial dysfunction in CHD patients.
  • These vitamins significantly affect the severity of vascular endothelial dysfunction in individuals with coronary heart disease.
  • Maintaining adequate levels of these vitamins may be crucial for managing endothelial function in CHD.

Keywords:
25-hydroxy vitamin D3coronary heart diseasevitamin B12vitamin C

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