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Updated: Jan 30, 2026

Cell Labeling and Targeting with Superparamagnetic Iron Oxide Nanoparticles
Published on: October 19, 2015
Polymer-coated superparamagnetic iron oxide nanoparticles as T2 contrast agent for MRI and their uptake in liver
Lamiaa Ma Ali1,1, Pasquina Marzola2,2, Elena Nicolato3,3
1Instituto de Ciencia de Materiales de Aragón, CSIC - Universidad de Zaragoza; & Departamento de Física de la Materia Condensada, Facultad de Ciencias, 50009 Zaragoza, Spain.
Aim:
To study the efficiency of multifunctional polymer-based superparamagnetic iron oxide nanoparticles (bioferrofluids) as a T2 magnetic resonance contrast agent and their uptake and toxicity in liver.
Materials & Methods:
Mice were intravenously injected with bioferrofluids and Endorem®. The magnetic resonance efficiency, uptake and in vivo toxicity were investigated by means of magnetic resonance imaging (MRI) and histological techniques.
Results:
Bioferrofluids are a good T2 contrast agent with a higher r2/r1 ratio than Endorem. Bioferrofluids have a shorter blood circulation time and persist in liver for longer time period compared with Endorem. Both bioferrofluids and Endorem do not generate any noticeable histological lesions in liver over a period of 60 days post-injection.
Conclusion:
Our bioferrofluids are powerful diagnostic tool without any observed toxicity over a period of 60 days post-injection.
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