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Published on: October 16, 2016
Switching of biological therapies in Brazilian patients with rheumatoid arthritis
Juliana Miranda de Lucena Valim1,1, Fernanda Gomes Gonçalves Chaer1,1, Fernanda D'Oliveira Guimarães da Silveira2,2
1Médica assistente da Reumatologia da ISCMSP, Medicine Department/Rheumatology Division, Santa Casa de Misericórdia de São Paulo, São Paulo-SP/CEP 01221-900, Brazil.
Aim:
To assess drug switching, rates of remission and disease activity in Brazilian patients with rheumatoid arthritis (RA) treated with biologic agents.
Materials & Methods:
Using a retrospective method, a total of 94 adult patients were included.
Results:
Anti-TNF was the first choice therapy in 85 (90.4%) patients. After an average of 8 years of follow-up, 55 (59%) patients were taking anti-TNF, 18 (19%) abatacept, eight (9%) tocilizumab and 13 (14%) rituximab. In this period, 99 switches of biological therapy were registered in 55 patients.
Conclusion:
After 8 years of follow-up, 54% of the RA patients on biological therapy were still experiencing high or moderate activity despite established treatment, including switching between different biologic agents.
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