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Additive Manufacturing-Enabled Low-Cost Particle Detector
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Additively Manufactured Flow-Resistive Pulse Sensors
Sarah M Hampson1, Marcus Pollard1, Peter Hauer2
1Department of Chemistry , Loughborough University , Loughborough , Leicestershire LE11 3TU , United Kingdom.
Analytical Chemistry
|January 18, 2019
Summary
We developed a rapid, additive manufacturing method for fabricating reusable resistive pulse sensors (RPSs). This 3D-printed sensor enables facile particle characterization and analysis across various conditions.
Area of Science:
- Nanotechnology
- Materials Science
- Biophysics
Background:
- Resistive pulse sensors (RPSs) offer particle-by-particle characterization from nanoparticles to biological cells.
- Traditional RPS fabrication often involves complex lithographic processes.
Purpose of the Study:
- To present a facile and rapid method for producing flow-RPSs using additive manufacturing.
- To demonstrate the control over channel dimensions and reusability of the fabricated sensors.
Main Methods:
- Additive manufacturing (3D printing) to create sensors with controlled channel dimensions.
- Experiments and simulations to analyze pulse shapes, particle counting, and sizing.
- Integration with fluidic pumps for pressure-driven flow and optical microscopy.
Main Results:
- Demonstrated facile assembly, disassembly, cleaning, and reuse of the additively manufactured RPS.
- Showcased the dependence of pulse shapes on channel morphology.
- Achieved rapid particle characterization down to 1 × 10-3 particles/mL, equivalent to one event per second.
Conclusions:
- Additive manufacturing provides a rapid and versatile approach for fabricating customizable resistive pulse sensors.
- The developed flow-RPSs enable efficient and sensitive particle analysis with potential for integrated optical detection.
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