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D3Oncoprint: Stand-Alone Software to Visualize and Dynamically Explore Annotated Genomic Mutation Files.

Alida Palmisano¹, Yingdong Zhao¹, Richard M Simon¹

¹All authors: National Cancer Institute, Rockville, MD.

JCO Clinical Cancer Informatics

|January 18, 2019

Summary

This summary is machine-generated.

D3Oncoprint is a free, standalone application that visualizes genomic mutation data for biomedical researchers. It enables interactive exploration of complex genomic datasets on local machines without requiring programming skills, facilitating biologic discovery and patient management.

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Area of Science:

Genomics
Bioinformatics
Cancer Research

Background:

Next-generation sequencing has increased genomic data availability, necessitating efficient analysis tools.
Current genomic analysis tools often require advanced programming skills or external web services, creating barriers for researchers.
Effective visualization and analysis are crucial for translating genomic data into biologic insights and clinical applications.

Purpose of the Study:

To develop a user-friendly, standalone application for interactive genomic data exploration on local machines.
To lower the barriers for biomedical researchers in analyzing complex genomic mutation data.
To facilitate the use of genomic data for biologic discovery and patient management.

Main Methods:

Developed D3Oncoprint, a standalone application for visualizing and exploring annotated genomic mutation files.
Integrated links to curated variant lists (CIViC, My Cancer Genome, OncoKB) and FDA-approved drugs.
Included curated gene lists from BioCarta pathways and FoundationOne cancer panels for exploring biologic processes.

Main Results:

D3Oncoprint provides a flexible environment for dynamic exploration of genomic mutation profiles.
The software facilitates interactive visualization with integrated biologic and medical annotations.
Researchers can explore their own genomic data without extensive computational expertise.

Conclusions:

D3Oncoprint empowers researchers to translate genomic data into biologic insights and clinical development.
The tool significantly lowers barriers for biomedical investigators working with complex genomics data.
D3Oncoprint is freely available for noncommercial use, promoting wider accessibility.