Computer-Assisted Flagging of Individuals at High Risk of Colorectal Cancer in a Large Health Maintenance

Ran Goshen1, Eran Choman1, Ayelet Ran1

  • 1Ran Goshen, Eran Choman, Ayelet Ran, and Efrat Muller, Medial EarlySign, Kfar Malal; Revital Kariv, Gabriel Chodick, and Varda Shalev; Maccabi Institute for Research and Innovation, Maccabi Healthcare Services; Nachman Ash, Maccabi Healthcare Services, Tel-Aviv; Revital Kariv, Gabriel Chodick, and Varda Shalev, Tel Aviv University; Revital Kariv, Sourasky Medical Center; Nachman Ash, Ariel University, Ariel, Israel; and Steven Narod, Women's College Research Institute, Women's College Hospital, and Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.

Summary

An automated system using ColonFlag identified high-risk individuals for colorectal cancer (CRC) who avoid screening. This approach successfully detected numerous CRCs among noncompliant patients, enhancing early cancer detection.

Related Concept Videos

Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
6.0K
Impact of Individuals on Individuals01:30

Impact of Individuals on Individuals

Human behavior is intricately shaped by social influences that arise from interactions with others in diverse contexts. These influences not only mold beliefs and attitudes but also drive the regulation of behaviors through both direct communication and observational learning. The study of these processes falls within the domain of social psychology, which seeks to understand how individuals are affected by and affect those around them.Mechanisms of Social InfluenceDirect social influence...
381
Relative Risk01:12

Relative Risk

Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.1K
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
2.8K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.5K
Health Literacy01:21

Health Literacy

Health literacy is an individual's or a community's capacity to comprehend, receive, read, and use relevant healthcare information and services. The World Health Organization (WHO, 2018) defines health literacy as the cognitive and social skills that determine the ability of individuals to gain access to, understand, and use information in ways that promote and maintain good health. As a result, the WHO helps individuals manage long-term health concerns, participate in preventative...
5.4K