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Natural history of experimental arthritis induced by Paracoccidioides brasiliensis in wistar rats
Eduardo Alexandre Loth1, Vanessa Cecatto1, Rodrigo Daniel Genske2
1Laboratório Experimental de Microbiologia e Análises Clínicas, Ensino, Pesquisa e Extensão, Universidade Estadual do Oeste do Paraná, Cascavel, PR, Brasil.
Introduction:
Paracoccidioidomycosis (PCM) is the most prevalent systemic mycosis in Latin America. This study aimed to evaluate the natural history of Paracoccidioides brasiliensis-induced experimental arthritis of the knee joints in Wistar rats.
Methods:
Rats were randomly allocated to either an absolute control group, or 15-day, 45-day, or 90-day experimental (fungus-inoculated) groups.
Results:
Experimental groups developed classic signs of articular PCM. Titers of anti-gp43 were observed to increase during the interval from 15 to 45 days post-inoculation.
Conclusions:
Articular arthritic lesions were induced and progressed during the study period in all experimental groups.
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