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Updated: Jan 30, 2026

Anti-virulent Disruption of Pathogenic Biofilms using Engineered Quorum-quenching Lactonases
Published on: January 1, 2016
Anti-Candida and anti-quorum sensing activity of airborne microorganisms detected by a rapid method
Andria Lopes Cruz1, Fabiana Silva de Souza1, Maxwel Adriano Abegg1,2
1Curso de Farmácia, Instituto de Ciências Exatas e Tecnologia, Universidade Federal do Amazonas, Itacoatiara, AM, Brasil.
Introduction:
Introducing new antibiotics to the clinic is critical.
Methods:
We adapted a plate method described by Kawaguchi and coworkers in 20131 for detecting inhibitory airborne microorganisms.
Results:
We obtained 51 microbial colonies antagonist to Chromobacterium violaceum, purified and retested them, and of these, 39 (76.5%) were confirmed. They comprised 24 bacteria, 13 fungi, and 2 yeasts. Among the fungi, eight (61.5%) produced active extracts. Among the bacterial, yeast, and fungal strains, 17 (44.7%) and 12 (31.6%) were active against Candida albicans and Candida parapsilosis, respectively.
Conclusions:
The proposed screening method is a rapid strategy for discovering potential antibiotic producers.
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