Related Experiment Video
Updated: Jan 30, 2026
09:06
Cochlear Implant Surgery and Electrically-evoked Auditory Brainstem Response Recordings in C57BL/6 Mice
Published on: January 9, 2019
14.7K
Impact of cochlear tonotopy on electrically evoked compound action potentials (ECAPs)
Florian Christov1,2, Michael B Gluth2, Stefan Hans1
1a Department of ENT , Universitatsklinikum Essen , Essen , Germany.
Acta Oto-Laryngologica
|January 18, 2019
Summary
Cochlear implant electrode type and placement significantly impact auditory nerve response. Perimodiolar arrays perform best in the cochlea's base, while lateral wall arrays excel in the apex, influencing programming decisions.
Area of Science:
- Otolaryngology
- Biomedical Engineering
- Neuroscience
Background:
- Cochlear implants utilize various electrode designs, including lateral wall and perimodiolar arrays.
- Lateral wall electrodes are thin, potentially preserving residual hearing.
- Perimodiolar electrodes are positioned near the auditory nerve, beneficial for profound hearing loss.
Purpose of the Study:
- To compare the effects of lateral wall and perimodiolar cochlear implant electrode designs on auditory nerve interaction.
- To analyze these effects across different tonotopic regions of the cochlea.
Main Methods:
- Retrospective analysis of adult and pediatric cochlear implant recipients using CI24RE/CI512 or CI422 devices.
- Evaluation of threshold Neural Response Telemetry (tNRT) data collected 12 months post-surgery.
- Comparison of tNRT thresholds based on electrode array type and tonotopic location.
Main Results:
- 168 cochlear implants were analyzed.
- Perimodiolar arrays showed lower thresholds in the basal cochlear region.
- Lateral wall (straight) arrays demonstrated lower thresholds in the apical cochlear region.
- Both array types exhibited highest thresholds in the medial cochlear regions.
Conclusions:
- Electrode type and intra-cochlear location influence tNRT.
- These findings are crucial for pre-operative selection of electrode arrays.
- Consideration of these factors is also vital for post-operative cochlear implant programming.
Related Concept Videos
01:41Action Potentials
142.1K
Overview
142.1K
01:31Action Potential
4.6K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
4.6K
01:14Action Potential
11.2K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they receive...
11.2K
01:23Propagation of Action Potentials
9.4K
The propagation of an action potential refers to the process by which a nerve impulse, or "action potential," travels along a neuron.
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
Neurons (nerve cells) have a resting membrane potential, with a slightly negative charge inside compared to outside. This is maintained by ion channels, such as sodium (Na+) and potassium (K+) channels, which control the flow of ions. When a stimulus, like a touch or a signal from another neuron, triggers the neuron, sodium channels open, allowing sodium ions to...
9.4K
01:30Cardiac Action Potential
6.3K
Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
6.3K
01:16Electric Potential and Potential Difference
5.7K
Suppose a positive test charge moves away from a positive static charge, then the Coulomb force does positive work, and its electric potential energy decreases. The potential energy per unit charge is defined as the electric potential. The electric potential is independent of the test charge.
When a test charge moves from the initial to the final position, the electric potential difference between those positions is defined as the ratio of the change in the potential energy to the charge on the...
When a test charge moves from the initial to the final position, the electric potential difference between those positions is defined as the ratio of the change in the potential energy to the charge on the...
5.7K