Related Experiment Video
Updated: Jan 30, 2026
07:35
Author Spotlight: A Computational Pipeline for Analyzing Chimeric Noncoding RNA-Target RNA Interactions in High-Throughput Sequencing Data
Published on: December 1, 2023
1.2K
Long noncoding RNA polymorphisms influence susceptibility to endemic pemphigus foliaceus
S C Lobo-Alves1, D G Augusto1,2, W C S Magalhães3,4
1Laboratório de Genética Molecular Humana, Departamento de Genética, Universidade Federal do Paraná, Curitiba, Brazil.
The British Journal of Dermatology
|January 18, 2019
Summary
Genetic variations in long noncoding RNA (lncRNA) genes are linked to pemphigus foliaceus (PF) susceptibility. This study identifies specific single-nucleotide polymorphisms (SNPs) associated with this autoimmune disease.
Area of Science:
- Genetics
- Immunology
- Molecular Biology
Background:
- Pemphigus foliaceus (PF) is an autoimmune disease targeting desmoglein 1, influenced by genetic and environmental factors.
- Long noncoding RNAs (lncRNAs) are implicated in gene regulation and complex disease pathogenesis.
- Single-nucleotide polymorphisms (SNPs) in lncRNA genes may affect disease risk.
Purpose of the Study:
- To investigate the association between SNPs in lncRNA genes and susceptibility to endemic pemphigus foliaceus.
- To identify specific lncRNA genetic variations contributing to PF development.
Main Methods:
- Integrated lncRNA SNP database with genome-wide genotype data.
- Analyzed 2080 SNPs in lncRNAs for association with PF in 229 patients and 6681 controls using logistic regression.
Main Results:
- Identified a significant association between SNP rs7144332 in lncRNA gene AL110292·1 and PF (OR = 1·63, P = 2·8 × 10-6).
- Five additional SNPs showed suggestive association (P < 0·001).
- In silico analysis indicated potential impacts on transcription, lncRNA structure, and microRNA interactions for these SNPs.
Conclusions:
- Demonstrated that variations in lncRNA genes can influence pemphigus pathogenesis.
- Highlighted the role of lncRNA variation in autoimmune diseases.
- Suggested specific polymorphisms for further functional validation in complex diseases.
More Related Videos
Related Concept Videos
01:53RNA Stability
35.7K
Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.7K
01:31Magnetic Susceptibility and Permeability
2.4K
In linear magnetic materials, like paramagnets and diamagnets, magnetization is proportional to the magnetic field intensity. The constant of proportionality, a dimensionless number, is called magnetic susceptibility. The value of the susceptibility depends on the type of material.
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
When diamagnetic materials are placed under an external magnetic field, the moments opposite to the field are induced. Hence, the susceptibility for diamagnets has a minimal negative value of 10-5–10-6. Since...
2.4K
01:05Single Nucleotide Polymorphisms-SNPs
18.3K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
18.3K
01:26Susceptibility, Permittivity and Dielectric Constant
2.9K
When placed in an external electric field, a dielectric material gets polarized. The charge density in the dielectric material is given by the sum of the bound and free charge densities, while the total charge density can also be written in terms of the total electric field. The bound charge density can be measured in terms of polarization, leading to the relationship between electric displacement and polarization.
2.9K
01:23RNA Interference
28.0K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
28.0K
01:21Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
716
Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
716