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Updated: Jan 30, 2026

Author Spotlight: A Streamlined Approach to Studying Cell Death Initiation in Hypersensitive Response
Published on: November 10, 2023
Ferroptosis: The Greasy Side of Cell Death
José Pedro Friedmann Angeli1, Sayuri Miyamoto2, Almut Schulze3
1Rudolf Virchow Center for Experimental Biomedicine , University of Würzburg , 97080 Würzburg , Germany.
Abstract:
Ferroptosis is a form of cell death that requires phospholipid peroxidation and has attracted increased attention, both as a means to eradicate tumors resistant to standard chemotherapy and for its potential contribution to tissue damage such as in ischemia/reperfusion. The center stage taken by phospholipid peroxidation in ferroptosis is highlighted by recent discoveries that demonstrate an intricate regulation of both the metabolism of polyunsaturated fatty acids as well as mechanisms leading to their oxidation. These metabolic steps converge at the point of ferroptosis execution through mechanisms that are now only starting to be understood. In this short review, we provide an appraisal of some of the recent advances in the understanding of the ferroptosis process and also provide some perspectives of where this knowledge could take us.
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