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Updated: Jan 30, 2026
09:12
Measuring Deformability and Red Cell Heterogeneity in Blood by Ektacytometry
Published on: January 12, 2018
15.5K
Red blood cell storage lesion: causes and potential clinical consequences
Tatsuro Yoshida1, Michel Prudent2,3, Angelo D'alessandro4
1Hemanext, Lexington, MA, United States of America.
Blood Transfusion = Trasfusione Del Sangue
|January 18, 2019
Summary
Red blood cell (RBC) storage causes damage, known as storage lesions, due to metabolite changes and oxidative stress. These lesions may impact transfusion outcomes, prompting research into interventions.
Area of Science:
- Hematology
- Cell Biology
- Biochemistry
Background:
- Red blood cells (RBCs) are vital for oxygen transport, fueling cellular energy production through oxidative phosphorylation.
- RBCs have evolved specialized features for oxygen delivery but face damage accumulation during their lifespan.
- Hypothermic storage in blood banks induces "storage lesions," compromising RBC function over time.
Purpose of the Study:
- To provide a comprehensive review of RBC storage lesions and their clinical implications.
- To integrate findings from traditional literature and recent "omics" technologies.
- To organize information on root causes, lesions, physiological effects, and outcomes of RBC storage.
Main Methods:
- Literature review incorporating traditional and "omics" data.
- Organization of information into four key panels: root causes, lesions, physiological effects, and outcomes.
- Analysis of interventions and recent clinical trial data on stored blood age and outcomes.
Main Results:
- Storage lesions stem from metabolite accumulation/depletion and oxidative damage.
- Physiological consequences of storage lesions are primarily studied in vitro.
- Potential links between storage lesions and clinical outcomes are discussed.
Conclusions:
- RBC storage lesions are a significant concern with potential clinical consequences.
- Interventions aim to mitigate storage lesion development and its effects.
- Ongoing research and clinical trials investigate the impact of stored blood age on transfusion outcomes.
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