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Related Concept Videos

Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
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In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
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Related Experiment Video

Updated: Jan 30, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
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Risk Factors for New-Onset Atrial Fibrillation in Patients With Sepsis: A Systematic Review and Meta-Analysis.

Nicholas A Bosch1, David M Cohen1, Allan J Walkey1,2

  • 1Department of Medicine, Boston University School of Medicine, The Pulmonary Center, Boston, MA.

Critical Care Medicine
|January 18, 2019
PubMed
Summary
This summary is machine-generated.

New-onset atrial fibrillation in sepsis is linked to acute sepsis factors, not typical community risk factors. Identifying these sepsis-specific risks, like corticosteroid use and vasopressor therapy, aids prevention and clinical management.

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Area of Science:

  • Critical Care Medicine
  • Cardiology
  • Epidemiology

Background:

  • Atrial fibrillation (AF) is a common complication in sepsis, increasing patient morbidity and mortality.
  • The specific risk factors for developing new-onset AF during sepsis remain poorly understood.
  • Clarifying these risk factors is crucial for understanding AF mechanisms and improving sepsis patient care.

Purpose of the Study:

  • To systematically review and meta-analyze identified risk factors for new-onset atrial fibrillation in patients with sepsis.
  • To compare sepsis-associated AF risk factors with those of community-associated AF.

Main Methods:

  • Systematic review and meta-analysis of studies indexed in Medline, Embase, Web of Science, and Cochrane CENTRAL.
  • Extraction and analysis of adjusted odds ratios for risk factors of new-onset AF in sepsis.
  • Pooled odds ratios calculated for factors appearing in multiple studies.

Main Results:

  • Eighteen of 44 examined factors were included in meta-analyses, encompassing demographic, comorbid, and sepsis-related factors.
  • Sepsis-related factors significantly increasing AF risk included corticosteroid use, right heart catheterization, fungal infections, vasopressor use, and a mean arterial pressure target of 80-85 mmHg.
  • Known community-associated AF risk factors were not consistently identified as risk factors in sepsis.

Conclusions:

  • Risk factors for new-onset AF in sepsis are primarily linked to the acute septic event, differing from community-acquired AF.
  • Findings highlight key areas for sepsis management, including glucocorticoid administration, vasopressor selection, and blood pressure targets.
  • Results provide a foundation for future research into AF prevention strategies in sepsis patients.