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Does retinopathy predict stroke recurrence in type 2 diabetes patients: A retrospective study?
Ola Hjelmgren1,2, Ulf Strömberg3, Karl Gellerman1
1The Wallenberg Laboratory, Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Plos One
|January 18, 2019
Summary
Diabetic retinopathy does not increase stroke recurrence risk in type 2 diabetes patients. While diabetes increases carotid stenosis risk, retinopathy itself does not further elevate this risk or stroke recurrence.
Area of Science:
- Neurology
- Ophthalmology
- Endocrinology
Background:
- Type 2 diabetes mellitus is a significant risk factor for cerebrovascular events.
- Diabetic retinopathy is a common microvascular complication of diabetes.
- The interplay between diabetic retinopathy, stroke recurrence, and carotid stenosis requires further elucidation.
Purpose of the Study:
- To investigate if retinopathy increases stroke recurrence risk in type 2 diabetes patients.
- To compare stroke recurrence risk between diabetic and non-diabetic patients.
- To assess the incidence of carotid stenosis in type 2 diabetes patients, with and without retinopathy.
Main Methods:
- A cohort study included 445 patients with type 2 diabetes mellitus and 445 matched non-diabetic controls, all first-time stroke or TIA patients.
- Data on retinopathy, risk factors, and stroke recurrence were collected from registers and medical records.
Main Results:
- Retinopathy did not significantly increase stroke recurrence risk in diabetes patients (HR 0.89).
- Diabetic patients did not exhibit an increased risk of stroke recurrence compared to non-diabetics.
- Diabetes patients showed a significantly higher prevalence of carotid stenosis (1.69-fold increase).
- Diabetic retinopathy did not correlate with an increased prevalence of carotid stenosis.
Conclusions:
- Diabetic retinopathy is not a predictor of stroke recurrence in type 2 diabetes.
- Diabetic retinopathy does not predict carotid stenosis in type 2 diabetes patients.
- Type 2 diabetes itself is associated with an increased risk of carotid stenosis.
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