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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Sensory Functions of the Skin01:16

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The skin is the largest organ of the human body and plays a crucial role in our sensory perception. It contains a vast network of sensory receptors that contribute to the skin's protective function by perceiving physical, biological, and environmental cues and generating relevant responses.
There are two main categories of receptors on the skin: capsulated and non-capsulated. The non-capsulated ones are mainly the pain receptors. The capsulated ones can be further categorized based on the...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Role of Skin in Vitamin D Synthesis01:23

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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Accessory Structures of the Skin: Nails01:05

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Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Related Experiment Video

Updated: Jan 30, 2026

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin
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Uncommon Neonatal Skin Lesions.

Jamie Rosen Manning, Diana H Lee

    Pediatric Annals
    |January 18, 2019
    PubMed
    Summary

    Prompt recognition of newborn rashes and skin lesions is crucial for diagnosing serious conditions like Langerhans cell histiocytosis and various cancers. Early evaluation guides timely management of these cutaneous findings.

    Area of Science:

    • Neonatal dermatology
    • Pediatric pathology
    • Clinical diagnostics

    Background:

    • Newborn skin manifestations can indicate serious underlying diseases.
    • Timely diagnosis and management are essential for improving infant outcomes.
    • A wide spectrum of conditions present with cutaneous findings in neonates.

    Purpose of the Study:

    • To review cutaneous findings in newborns that may signal serious conditions.
    • To guide healthcare providers in the diagnosis and management of neonatal skin lesions.
    • To highlight the importance of early recognition of specific dermatological signs.

    Main Methods:

    • Review of literature on neonatal rashes and cutaneous lesions.
    • Discussion of diagnostic criteria for various associated conditions.

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  • Synthesis of information to guide clinical evaluation and management strategies.

    • Main Results:

    • Identified key cutaneous findings associated with Langerhans cell histiocytosis.
    • Detailed the presentation of cutaneous cancers (leukemia cutis, neuroblastoma, rhabdomyosarcoma) in newborns.
    • Outlined dermatological signs of developmental abnormalities (neural tube/spinal dysraphism), aplasia cutis congenita, nutritional deficiencies, and immunodeficiencies.

    Conclusions:

    • Certain newborn rashes and skin lesions are critical indicators of potentially severe diseases.
    • Prompt and accurate diagnosis based on cutaneous findings is vital for effective treatment.
    • This review provides a framework for recognizing and managing concerning neonatal dermatological presentations.