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Related Experiment Video

Updated: Jan 30, 2026

Isolation and Culture of Primary Mouse Keratinocytes from Neonatal and Adult Mouse Skin
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Neonatal Skin Emergencies.

Mark Siegel, Lara Wine Lee

    Pediatric Annals
    |January 18, 2019
    PubMed
    Summary

    Neonatal skin rashes can signal serious infections or underlying disorders requiring immediate medical attention. Differentiating these dermatologic emergencies from benign conditions is crucial for prompt diagnosis and treatment in newborns.

    Area of Science:

    • Neonatal Dermatology
    • Pediatric Infectious Diseases
    • Clinical Pediatrics

    Background:

    • Most neonatal skin rashes are benign and do not require intervention.
    • However, a subset of neonatal rashes represent dermatologic emergencies requiring urgent assessment.

    Purpose of the Study:

    • To distinguish between benign neonatal skin rashes and those indicative of dermatologic emergencies.
    • To highlight key clinical clues for identifying neonatal dermatologic emergencies.

    Main Methods:

    • Review of literature on neonatal dermatologic emergencies.
    • Identification of cutaneous findings associated with serious infections and underlying disorders in neonates.

    Main Results:

    • Neonatal skin can be the initial indicator of infections like herpes simplex virus, syphilis, varicella, cytomegalovirus, fungal infections, and staphylococcal scalded skin syndrome.

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  • Specific cutaneous findings such as purpura fulminans, sclerema neonatorum, neonatal lupus, and blueberry muffin rash may signal other significant underlying conditions.

    • Conclusions:

    • Prompt recognition and diagnosis of specific neonatal skin findings are essential for timely intervention.
    • Early identification of dermatologic emergencies can prevent severe sequelae and guide further evaluation of neonates.