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Updated: Jan 30, 2026
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Fiber Connections of the Supplementary Motor Area Revisited: Methodology of Fiber Dissection, DTI, and Three Dimensional Documentation
Published on: May 23, 2017
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The supplementary motor area modulates interhemispheric interactions during movement preparation
Quentin Welniarz1,2, Cécile Gallea1, Jean-Charles Lamy1
1Faculté de Médecine, INSERM U 1127, CNRS UMR 7225, Institut du Cerveau et de la Moelle épinière, Sorbonne Université, Paris, France.
Human Brain Mapping
|January 18, 2019
Summary
The supplementary motor area (SMA) regulates interhemispheric interactions for coordinated hand movements. Disrupting the SMA or studying congenital mirror movements revealed its crucial role in preparing bimanual actions.
Area of Science:
- Neuroscience
- Motor Control
- Cognitive Neuroscience
Background:
- Coordinated hand movements involve complex interactions between motor areas in both brain hemispheres.
- The supplementary motor area (SMA) is implicated in movement preparation and bimanual coordination.
- The precise role of the SMA in modulating interhemispheric interactions for bimanual control is not fully understood.
Purpose of the Study:
- To investigate interhemispheric interactions during movement preparation.
- To elucidate the role of the supplementary motor area (SMA) in these interactions.
- To examine SMA's function during the delay period of unimanual and bimanual hand movements.
Main Methods:
- Utilized functional MRI (fMRI) and transcranial magnetic stimulation (TMS) in healthy volunteers.
- Investigated two models of SMA dysfunction: temporary disruption via TMS and congenital mirror movements (CMM).
- Employed a delayed-response task to assess movement preparation and interhemispheric connectivity.
Main Results:
- Interhemispheric connectivity varied based on the requirement for hand coordination in healthy volunteers.
- SMA disruption and CMM models showed altered interhemispheric connectivity and reduced inhibition during the delay period.
- These findings demonstrate the SMA's modulation of interhemispheric interactions during movement preparation.
Conclusions:
- The supplementary motor area (SMA) plays a significant role in modulating interhemispheric interactions.
- This modulation is critical for the preparation of coordinated bimanual movements.
- Unveiling a novel function for the SMA in motor control and coordination.
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