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High-throughput Carbonyl Content Method of Therapeutic mAb using size-exclusion chromatography with ultraviolet and

Yunyu Yi1, Li Zang1

  • 1Analytical Development, Biogen, Cambridge, MA, 02142, USA.

Analytical Biochemistry
|January 18, 2019
PubMed

Keywords:
AscorbateCysteineCystineFenton reactionFluorescein thiosemicarbazide (FTC)FluorescenceFluorometricHPLCMetalsOxidationProtein carbonylationTherapeutic monoclonal antibody

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