Differential modulation of pressure pain threshold in response to transcutaneous spinal direct current stimulation...

This study investigated the interaction between physical activity level and responses to transcutaneous spinal direct current stimulation (tsDCS) as reflected in changes in pressure pain threshold (PPT) in the lower extremity. Participants (n = 35, 15 males) consisted of physically active young adults. PPTs were determined at three sites (thigh, leg and foot) on the dominant leg before and after 20-min of anodal tsDCS applied at mid-thoracic level. Based on a questionnaire, participants were assigned to either a low-moderately active (n = 21) or highly active group (n = 14). At baseline, participants in the two activity groups exhibited comparable PPTs. After the intervention, PPTs were significantly elevated at all sites at 5-min and 30-min post-tsDCS. An interaction was found between activity groups and tsDCS-induced changes at the thigh site owing to a larger elevation in PPTs in the highly active group. These results corroborate previous findings regarding antalgic effects of tsDCS and point to the role of physical activity level as a potential factor susceptible to modulate responses to tsDCS interventions.