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In-situ dissolution and permeation studies of nanocrystal formulations with second-derivative UV spectroscopy

Masaaki Imono1, Hiromasa Uchiyama2, Hiroshi Ueda3

  • 1Osaka University of Pharmaceutical Sciences, 4-20-1 Nasahara, Takatsuki, Osaka 569-1094, Japan; Physicochemical and Preformulation, Applied Chemistry and Analysis, Research Laboratory for Development, Shionogi & Co Ltd., 3-1-1 Futaba-cho, Toyonaka-shi, Osaka 561-0825, Japan.

International Journal of Pharmaceutics
|January 18, 2019
PubMed

Keywords:
Dissolution rateDissolution-permeation studyMefenamic acidNanocrystalSecond-derivative UV analysis

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