Related Experiment Video
Updated: Jan 30, 2026

A Method to Study de novo Formation of Chromatin Domains
Published on: August 23, 2019
De novo formation and epigenetic maintenance of centromere chromatin
Junichirou Ohzeki1, Vladimir Larionov2, William C Earnshaw3
1Laboratory of Chromosome Engineering, Department of Frontier Research and Development, Kazusa DNA Research Institute, 2-6-7 Kazusa-Kamatari, Kisarazu 292-0818, Japan.
Abstract:
Accurate chromosome segregation is essential for cell proliferation. The centromere is a specialized chromosomal locus, on which the kinetochore structure is formed. The centromere/kinetochore is required for the equal separation of sister chromatids to daughter cells. Here, we review recent findings on centromere-specific chromatin, including its constitutive protein components, its de novo formation and maintenance mechanisms, and our progress in analyses with synthetic human artificial chromosomes (HACs).
Related Concept Videos
Inheritance of Chromatin Structures
Histone Variants at the Centromere
Epigenetic Regulation
Epigenetic Regulation
X-chromosome...
Chromatin Packaging
The chromatin
In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order...
Chromatin Position Affects Gene Expression
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...

