Related Experiment Video

Updated: Jan 30, 2026

Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent
06:46

Non-invasive In Vivo Fluorescence Optical Imaging of Inflammatory MMP Activity Using an Activatable Fluorescent Imaging Agent

Published on: May 8, 2017

9.3K

MT4-MMP: The GPI-Anchored Membrane-Type Matrix Metalloprotease with Multiple Functions in Diseases

Cassandre Yip1, Pierre Foidart2, Agnès Noël3

  • 1Laboratory of Tumor and Development Biology, Groupe Interdisciplinaire de Génoprotéomique Appliqué-Cancer (GIGA-Cancer), University of Liège, Liège 4000, Belgium. cassandre.yip@uliege.be.

International Journal of Molecular Sciences
|January 19, 2019
PubMed

Insights

Membrane-Type Matrix Metalloproteinase 4 (MT4-MMP) is a unique protease involved in tissue remodeling. This review explores its biological roles and potential as a therapeutic target, especially in cancer progression.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Membrane-Type Matrix Metalloproteinases (MT-MMPs) are crucial for extracellular matrix remodeling in physiological processes.
  • MT4-MMP (MMP17) exhibits unique characteristics in sequence, substrate specificity, and internalization compared to other MT-MMPs.
  • The precise physiological roles of MT4-MMP remain largely undefined, but it is implicated in pathological conditions.

Purpose of the Study:

  • To review the biological and structural properties of MT4-MMP (MMP17).
  • To provide an overview of the known physiological and pathological functions of MT4-MMP.
  • To highlight MT4-MMP as a potential therapeutic target, particularly in cancer.

Main Methods:

  • Literature review of existing studies on MT4-MMP (MMP17).
  • Analysis of sequence homology, substrate specificity, and internalization mechanisms.
  • Examination of MT4-MMP's involvement in various cancers and other pathologies.

Main Results:

  • MT4-MMP transcript is detected across a wide range of cancers, including gastric, colon, head and neck, and breast cancers.
  • Evidence suggests MT4-MMP contributes to tumor development and progression.
  • MT4-MMP is associated with pathologies like arthritis and cardiovascular disease.

Conclusions:

  • MT4-MMP possesses distinct properties suggesting unique functions.
  • Its significant role in cancer progression makes MT4-MMP a promising therapeutic target.
  • Further research into MT4-MMP's biology is warranted to fully understand its therapeutic potential.
Keywords:
MT4-MMPcancerdiseases

More Related Videos

Detection of Functional Matrix Metalloproteinases by Zymography09:30

Detection of Functional Matrix Metalloproteinases by Zymography

Published on: November 8, 2010

85.0K
Flow Cytometric Analysis of Multiple Mitochondrial Parameters in Human Induced Pluripotent Stem Cells and Their Neural and Glial Derivatives06:09

Flow Cytometric Analysis of Multiple Mitochondrial Parameters in Human Induced Pluripotent Stem Cells and Their Neural and Glial Derivatives

Published on: November 8, 2021

5.1K

Related Concept Videos

GPI Anchoring of Proteins in the ER Membrane01:29

GPI Anchoring of Proteins in the ER Membrane

GPI-anchoring is a post-translational, reversible protein modification that is ubiquitous in eukaryotes. Such proteins are primarily present on the exoplasmic leaflet of the plasma membrane.
GPI-anchor structure
A sequence of 11 enzymatic reactions results in the synthesis of the complete GPI anchor consisting of a hydrophobic and a hydrophilic portion. The hydrophobic portion comprises phosphatidylinositol, while the hydrophilic part comprises polar groups like phosphoethanolamine,...
5.5K
Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
3.4K
Tail-anchoring of Proteins in the ER Membrane01:45

Tail-anchoring of Proteins in the ER Membrane

Tail-anchored, or TA, proteins are estimated to make up to 3-5% of membrane proteins found in the eukaryotic cell. Such proteins have a single transmembrane domain located approximately 30 amino acid residues upstream from the C-terminal end. As a result, the signal recognition particle (SRP) cannot guide a TA protein to the ER membrane for cotranslational insertion. Hence, they are integrated into the ER membrane post-translationally using their C-terminal end as the anchor. TA proteins...
3.8K
The Anchoring-and-Adjustment Heuristic01:25

The Anchoring-and-Adjustment Heuristic

In order to make good decisions, we use our knowledge and our reasoning. Often, this knowledge and reasoning is sound and solid. However, sometimes, we are swayed by biases or by others manipulating a situation. For example, let’s say you and three friends wanted to rent a house and had a combined target budget of $1,600. The realtor shows you only very run-down houses for $1,600 and then shows you a very nice house for $2,000. Might you ask each person to pay more in rent to get the...
7.8K
Types of Functions I01:26

Types of Functions I

Functions are fundamental mathematical tools that capture relationships between variables and describe how one quantity changes in relation to another. Their diverse forms allow them to model various real-world phenomena with precision and flexibility. Among the various categories, algebraic functions are prominent due to their formulation through basic arithmetic operations: addition, subtraction, multiplication, division, and root extraction.Algebraic functions include polynomial, rational,...
304
Types of Membrane Protrusions01:28

Types of Membrane Protrusions

The protrusion of the cell surface is an initial step for several cellular processes, including cell migration, phagocytosis, and neurite outgrowth. These membrane protrusions are a result of cytoskeletal rearrangement. The most  widely observed cell protrusions include lamellipodia, pseudopodia, filopodia, microvilli, invadopodia, and podosomes. These protrusions can be of two types — static or dynamic.
The microvilli, an example of stable protrusions, are finger-like projections...
3.7K