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Related Experiment Videos

Mouse cachexia induced by trehalose dimycolate from Nocardia asteroides.

C L Silva1, I Tincani, S L Brandão Filho

  • 1Department of Parasitology, Microbiology and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil.

Journal of General Microbiology
|June 1, 1988
PubMed
Summary

Trehalose dimycolate (TDM) from Nocardia asteroides causes severe weight loss (cachexia) in mice. This immune response involves tumor necrosis factor and leads to significant mortality.

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Area of Science:

  • Immunology
  • Microbiology
  • Biochemistry

Background:

  • Trehalose dimycolate (TDM) is a component of Nocardia asteroides.
  • Cachexia is a severe wasting condition characterized by weight loss.

Purpose of the Study:

  • To investigate the effects of TDM on inducing cachexia in mice.
  • To identify potential mechanisms behind TDM-induced cachexia.

Main Methods:

  • Mice were injected intraperitoneally with TDM in mineral oil.
  • Doses and intervals of TDM administration were varied.
  • Weight loss, mortality, triglyceride levels, glucose levels, and plasma cytokine levels were monitored.

Main Results:

  • Multiple TDM injections led to 90% mortality within 26 days, preceded by weight loss and peritoneal inflammation.

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  • A single TDM dose induced rapid weight loss, hypertriglyceridemia, and hypoglycemia within 48 hours.
  • Tumor necrosis factor (TNF), also known as cachectin, was detected in the plasma of TDM-injected mice.

    • Conclusions:

    • TDM is a potent inducer of cachexia in mice.
    • The induction of cachexia by TDM is associated with hypertriglyceridemia, hypoglycemia, and inflammation.
    • Tumor necrosis factor (TNF) released by mononuclear phagocytes is implicated in TDM-induced cachexia.