Continuous exercise induces airway epithelium damage while a matched-intensity and volume intermittent exercise does
Adrien Combes1, Jeanne Dekerle2, Xavier Dumont3
1URePSSS, Unité de Recherche Pluridisciplinaire Sport, Santé, Société, Lille, France.
Respiratory Research
|January 19, 2019
Summary
Continuous exercise (CE) causes mild airway damage, unlike intermittent exercise (IE), with higher ventilation rates during CE correlating with this damage. This study investigated epithelial cell damage markers during and after matched exercise protocols.
Area of Science:
- Exercise Physiology
- Pulmonary Medicine
- Biomarkers
Background:
- Continuous exercise (CE) elicits higher ventilation than intermittent exercise (IE).
- The impact of CE versus IE on airway epithelial damage is not well understood.
- This study examines serum markers of airway epithelial damage following matched CE and IE protocols.
Purpose of the Study:
- To compare airway epithelial cell damage markers (CC16 and CC16/SP-D ratio) between continuous exercise and intermittent exercise.
- To investigate the relationship between ventilation and airway damage markers during different exercise modalities.
- To assess the effects of a single bout of CE versus IE on serum levels of CC16 and SP-D.
Main Methods:
- Sixteen healthy adults underwent 30-min CE and 60-min IE at 70% maximal work rate (WRmax).
- Ventilation, heart rate, lactate, CC16, and SP-D were measured at rest, during exercise, and post-exercise.
- Blood samples were collected at multiple time points to assess serum biomarker changes.
Main Results:
- Mean ventilation was significantly higher during CE compared to IE.
- Serum markers of epithelial damage (CC16, CC16/SP-D ratio) showed significant changes over time during CE but not IE.
- The increase in the CC16/SP-D ratio during CE was strongly correlated with mean ventilation.
Conclusions:
- A 30-minute bout of continuous exercise at 70% WRmax induces mild airway damage.
- Time- or work-matched intermittent exercise did not result in significant airway damage markers.
- The degree of airway damage during CE is associated with the sustained ventilation rate.
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