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Updated: Jan 22, 2026
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Murine Fecal Isolation and Microbiota Transplantation
Published on: May 26, 2023
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Microbiota and gastrointestinal cancer.
Meng-Tzu Weng1, Yu-Tse Chiu2, Ping-Ya Wei2
1Departments of Internal Medicine, National Taiwan University Hospital, Taipei City, Taiwan; Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan; Department of Chemical Engineering & Materials Science, Yuan-Ze University, Taoyuan, Taiwan.
Journal of the Formosan Medical Association = Taiwan Yi Zhi
|January 19, 2019
Summary
Gut microbiota influences cancer development through various mechanisms. Understanding these gut bacteria changes is key for developing future gastrointestinal cancer treatments.
Area of Science:
- Microbiology
- Oncology
- Gastroenterology
Background:
- Gut microbiota significantly impacts numerous diseases, including various cancers.
- Microbial dysbiosis can promote carcinogenesis via oxidative stress, genotoxicity, immune dysfunction, and chronic inflammation.
- The liver's direct exposure to gut-derived microbial products highlights the gut-liver axis in disease pathogenesis.
Purpose of the Study:
- To review the mechanisms by which gut microbiota influences carcinogenesis.
- To discuss alterations in gut microbiota composition associated with gastrointestinal cancers.
- To explore potential therapeutic strategies targeting the gut microbiota for cancer treatment.
Main Methods:
- Literature review of studies on gut microbiota and gastrointestinal cancers.
- Analysis of microbial changes in patients with colorectal, liver, and gastric cancers.
- Examination of the role of specific bacteria and their metabolites in cancer development.
Main Results:
- Distinct microbial profiles are observed in patients with precancerous lesions and gastrointestinal cancers compared to healthy individuals.
- Normalization of gut microbiota is noted post-colorectal cancer treatment.
- Helicobacter pylori and nitrosating bacteria are identified as risk factors for gastric cancer.
Conclusions:
- Gut microbiota plays a critical role in the development of gastrointestinal cancers.
- Targeting gut microbiota represents a promising avenue for future cancer therapies.
- Further research into microbiota-host interactions is essential for advancing cancer prevention and treatment.
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