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Updated: Jan 30, 2026

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Pupillary Response as Assessment of Effective Seizure Induction by Electroconvulsive Therapy
Published on: April 11, 2019
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Catastrophic Secondary Infarctions with Onset Seizure Following Tissue Plasminogen Activator Therapy
Kosuke Matsuzono1, Lisa Nagaoka1, Masayuki Suzuki1
1Division of Neurology, Department of Internal Medicine, Jichi Medical University School of Medicine, Shimotsuke, Tochigi, Japan.
Summary
Recombinant tissue-type plasminogen activator therapy can paradoxically cause multiple brain infarctions. This case highlights a rare complication in stroke patients with severe arterial stenosis.
Area of Science:
- Neurology
- Vascular Neurology
- Neurocritical Care
Background:
- Intravenous recombinant tissue-type plasminogen activator (IV rt-PA) is a standard treatment for acute ischemic stroke.
- Known fatal complications include intracranial hemorrhage, aortic dissection, and extracranial bleeding.
- The potential for IV rt-PA to induce synchronized multiple cerebral infarctions has not been previously considered.
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