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Cardiac allotransplantation across major blood group barriers in the baboon
D K Cooper1, G Lexer, A G Rose
1Department of Cardiothoracic Surgery, University of Cape Town Medical School Republic of South Africa.
Journal of Medical Primatology
|January 1, 1988
Abstract:
In heterotopic heart transplantation experiments in Chacma baboons, some of the animals were significantly immunosuppressed with cyclosporine, resulting in prolonged cardiac allograft survival. ABO blood group incompatibility between recipient and donor did not significantly influence mean allograft survival, but early hyperacute (vascular) or acute (cellular) rejection occurred only when ABO incompatibility was present.