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Downregulation of long noncoding RNA FENDRR predicts poor prognosis in renal cell carcinoma

Wang He1,2, Guangzheng Zhong1,2, Pei Wang3

  • 1Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China.

Oncology Letters
|January 19, 2019
PubMed

Insights

Long noncoding RNA FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR) is downregulated in renal cell carcinoma, acting as a tumor suppressor. Its restoration inhibits cancer cell growth and invasion, suggesting FENDRR as a therapeutic target.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • Dysregulation of long noncoding RNA FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR) is linked to various human cancers.
  • The specific role of FENDRR in renal cell carcinoma (RCC) remains largely unknown.

Purpose of the Study:

  • To investigate the expression patterns and functional significance of FENDRR in renal cell carcinoma.
  • To elucidate the underlying molecular mechanisms of FENDRR's action in RCC progression.

Main Methods:

  • Quantitative reverse transcription-polymerase chain reaction (RT-qPCR) for FENDRR expression analysis.
  • RNA interference and ectopic expression assays to assess FENDRR's impact on cell proliferation, migration, and invasion.
  • RNA immunoprecipitation (RIP) to identify FENDRR-interacting proteins.

Main Results:

  • FENDRR is significantly downregulated in renal cell carcinoma tissues compared to normal tissues.
  • Overexpression of FENDRR suppressed proliferation, migration, invasion, and colony formation of RCC cells.
  • Knockdown of FENDRR enhanced proliferation and invasiveness of RCC cells.
  • Lower FENDRR expression correlated with poorer prognosis in RCC patients.
  • FENDRR was found to interact with Polycomb Repressive Complex 2 and lysin methyltransferase 2A histone modifying complexes.

Conclusions:

  • FENDRR functions as a tumor suppressor in renal cell carcinoma.
  • FENDRR's downregulation is associated with adverse clinical outcomes in RCC.
  • FENDRR represents a potential therapeutic target for gene therapy in renal cell carcinoma.
Keywords:
RNA-protein interactionlong noncoding RNAmetastasisprognosisrenal cell carcinoma

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