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Updated: Jan 30, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
14:32

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates

Published on: February 27, 2016

8.6K

Sirtuin 1 and oral cancer

Shajedul Islam1, Yoshihiro Abiko2, Osamu Uehara1,3

  • 1Division of Disease Control and Molecular Epidemiology, Department of Oral Growth and Development, School of Dentistry, Health Sciences University of Hokkaido, Tobetsu, Hokkaido 061-0293, Japan.

Oncology Letters
|January 19, 2019
PubMed

Insights

Sirtuins (SIRTs) are histone deacetylases. This study explores SIRT1

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Sirtuins (SIRTs) are a family of seven conserved histone deacetylases (HDACs).
  • SIRT1 is extensively studied for its role in cancer biology.
  • The specific function of SIRT1 in oral cancer remains unclear, with conflicting research findings.

Purpose of the Study:

  • To elucidate the biological roles of SIRT1 in oral cancer.
  • To investigate the potential therapeutic implications of SIRT1 in oral cancer.
  • To clarify the function of SIRT1 in precancerous oral lesions and oral cancer.

Main Methods:

  • Literature review and synthesis of existing research on SIRT1.
  • Analysis of studies investigating SIRT1 in oral carcinogenesis.
  • Discussion of potential therapeutic strategies targeting SIRT1.

Main Results:

  • Contradictory findings exist regarding SIRT1's role in oral cancer.
  • SIRT1's involvement spans from precancerous lesions to advanced oral cancer.
  • Evidence suggests SIRT1 may act as both an oncogene and a tumor suppressor in oral cancer.

Conclusions:

  • SIRT1 plays a complex and debated role in oral cancer development and progression.
  • Further research is needed to fully understand SIRT1's mechanisms in oral cancer.
  • Targeting SIRT1 may offer novel therapeutic avenues for oral cancer treatment.
Keywords:
betel quidoral cancersirtuintransforming growth factor beta

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