Related Experiment Video

Updated: Jan 30, 2026

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices
04:09

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices

Published on: June 13, 2025

1.1K

Local suture ligation-assisted percutaneous sclerotherapy for Kasabach-Merritt phenomenon-associated kaposiform

Xiao Li1, Ming-Zhe Wen1, Li-Xin Su1

  • 1Department of Interventional Therapy, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, Shanghai 200011, P.R. China.

Oncology Letters
|January 19, 2019
PubMed

Insights

Kaposiform haemangioendotheliomas (KHEs) with Kasabach-Merritt phenomenon (KMP) are rare. Local suture ligation-assisted percutaneous sclerotherapy offers a safe, effective, and minimally invasive treatment option for these complex cases.

Area of Science:

  • Vascular lesions
  • Pediatric oncology
  • Interventional radiology

Background:

  • Kaposiform haemangioendotheliomas (KHEs) complicated by Kasabach-Merritt phenomenon (KMP) are rare, severe neoplastic lesions.
  • These conditions are associated with aggressive local disease, coagulopathy, and high mortality.
  • Current treatments often lack satisfactory efficacy, necessitating novel approaches.

Purpose of the Study:

  • To evaluate the safety and efficacy of local suture ligation-assisted percutaneous sclerotherapy for KHE/KMP.
  • To present a minimally invasive treatment strategy for complex KHE/KMP cases.
  • To assess clinical, radiological, pathological, and laboratory outcomes.

Main Methods:

  • A case series of 3 consecutive patients with KHE/KMP treated between September 2015 and September 2017.
  • Staged local suture ligation-assisted percutaneous sclerotherapy combined with pharmacotherapy.
  • Stepwise synthetic serial therapy programme including percutaneous sclerotherapy and suture ligation.

Main Results:

  • All 3 patients were successfully managed with the described procedure.
  • Significant improvement in clinical symptoms and haematological indicators was observed.
  • No recurrence or complications were noted during follow-up periods ranging from 4 to 28 months.

Conclusions:

  • Local suture ligation-assisted percutaneous sclerotherapy is a safe and effective minimally invasive treatment for KHE/KMP.
  • The procedure involves simple manipulation and offers clear benefits in select cases.
  • Further research with larger sample sizes is warranted to establish this as a novel therapeutic option.
Keywords:
Kasabach-Merritt phenomenoncoagulationkaposiform haemangioendotheliomasclerotherapysuture ligation

More Related Videos

Three-Dimensional Printing Guide Template Assisted Percutaneous Vertebroplasty PVP05:39

Three-Dimensional Printing Guide Template Assisted Percutaneous Vertebroplasty PVP

Published on: October 17, 2019

8.2K
Author Spotlight: Development and Application of a Novel Suture Technique for Annular Fibrosus Repair in Percutaneous Transforaminal Endoscopic Discectomy03:24

Author Spotlight: Development and Application of a Novel Suture Technique for Annular Fibrosus Repair in Percutaneous Transforaminal Endoscopic Discectomy

Published on: January 26, 2024

1.6K

Related Concept Videos

Tip-of-the-Tongue Phenomenon01:10

Tip-of-the-Tongue Phenomenon

The tip-of-the-tongue (TOT) phenomenon is a cognitive experience characterized by a temporary inability to retrieve specific information from memory despite having a strong feeling of knowing the information. Although individuals cannot access the target word or detail, they frequently recall related elements, such as its initial letter, syllable count, or context. This partial retrieval often causes frustration, as one might recognize a familiar face or know that a name starts with a specific...
518
Sutures of the Skull01:22

Sutures of the Skull

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
10.4K
Local Attraction01:22

Local Attraction

Local attraction refers to disturbances in compass readings caused by magnetic influences from nearby objects such as metal fences, buried pipes, vehicles, buildings, power lines, or natural iron ore deposits. Small items like wristwatches, steel tools, or belt buckles can also interfere with the compass by creating local magnetic fields that distort the Earth's natural magnetic field. These distortions lead to inaccurate readings, posing navigation and land surveying challenges.Local...
379
Local Anesthetics: Pharmacokinetics01:13

Local Anesthetics: Pharmacokinetics

The potency and duration of action of local anesthetics (LAs) are determined by their pharmacokinetics. Pharmacokinetics describes how LAs are absorbed, distributed, metabolized, and eliminated from the body. When administered to the vascular tissues, LAs are quickly absorbed and enter the systemic circulation, reducing their localized effects. Adding vasoconstrictors such as epinephrine to LAs reduces their absorption into the systemic circulation, making them clinically effective. The...
1.2K
Local Anesthetics: Adverse Effects01:12

Local Anesthetics: Adverse Effects

While local anesthetics are generally safe and well-tolerated, they can occasionally cause adverse effects that vary in severity. Local anesthetics can induce toxicity at two distinct levels. They can either produce local effects through direct contact with the neural elements or be absorbed into the bloodstream from the injection site, leading to systemic effects.
Once absorbed into the systemic circulation, local anesthetics can affect the organs that depend on the functioning of sodium...
799
Absolute and Local Extreme Values01:22

Absolute and Local Extreme Values

The highest and lowest values of a function, relative to a reference axis, are known as extreme values. These include absolute maximum and absolute minimum values, which represent the highest and lowest points the function reaches across its entire domain. Within a restricted portion of the function, the highest and lowest values are referred to as local maximum and local minimum values, respectively.Periodic functions, such as sine and cosine, show extreme values at infinitely many points due...
73