Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The periodic paralyses.

J E Riggs1

  • 1West Virginia University School of Medicine, Morgantown.

Neurologic Clinics
|August 1, 1988
PubMed
Summary
This summary is machine-generated.

Primary periodic paralyses are classified using patient history and examination. This review covers these muscle channel disorders, their treatments, and diagnostic provocative testing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The war on cancer: demonstrating the impact of aging upon cancer mortality.

Military medicine·2010
Same author

Medical ethics, logic traps, and game theory: an illustrative tale of brain death.

Journal of medical ethics·2004
Same author

Clinicopathological features of genetically confirmed Danon disease.

Neurology·2002
Same author

Creutzfeldt-Jakob disease and blood transfusions: a meta-analysis of case-control studies.

Military medicine·2002
Same author

Delayed diffuse neurodegeneration after cerebral concussion.

Military medicine·2001
Same author

The latency between traumatic axonal injury and the onset of amyotrophic lateral sclerosis in young adult men.

Military medicine·2001

Area of Science:

  • Neurology
  • Muscle Physiology
  • Genetics

Background:

  • Primary periodic paralyses are a group of rare inherited neuromuscular disorders.
  • These conditions are characterized by episodes of muscle weakness or paralysis.
  • Accurate diagnosis is crucial for effective management and patient care.

Purpose of the Study:

  • To review the primary periodic paralyses, including their classification and clinical presentation.
  • To discuss current treatment strategies for managing episodes of paralysis.
  • To highlight the role of provocative testing in diagnosing these channelopathies.

Main Methods:

  • Review of existing literature on primary periodic paralyses.
  • Analysis of diagnostic criteria and clinical examination findings.

Related Experiment Videos

  • Evaluation of the utility and safety of provocative testing protocols.

    • Main Results:

    • Patient history and physical examination are key to initial diagnosis.
    • Specific provocative tests can aid in differentiating between subtypes.
    • Sodium channel dysfunction is implicated as a common pathogenetic mechanism.

    Conclusions:

    • Primary periodic paralyses can often be diagnosed through careful clinical assessment.
    • Provocative testing is a valuable tool for confirming diagnosis and understanding disease mechanisms.
    • Targeting sodium channel dysfunction offers therapeutic potential for these disorders.