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Hematological malignancies during pregnancy
Merav Barzilai1, Irit Avivi1, Odelia Amit1
1Hematology and Hemato-Oncology Division, Tel Aviv Medical Center, Tel Aviv 6423906, Israel.
Molecular and Clinical Oncology
|January 19, 2019
Summary
Hematological malignancies during pregnancy are rare, necessitating careful maternal and fetal management. Treatment aims to prioritize maternal survival while minimizing fetal toxicity, often mirroring non-pregnant protocols.
Area of Science:
- Hematology
- Obstetrics
- Oncology
Background:
- Hematological malignancy in pregnancy is uncommon, with limited evidence from case studies and expert opinions.
- Management strategies require balancing maternal health, fetal well-being, and treatment efficacy.
Purpose of the Study:
- To review the diagnosis and management of common hematological malignancies during pregnancy.
- To synthesize current literature, clinical cases, and therapeutic options for this rare condition.
Main Methods:
- A narrative review of existing literature.
- Inclusion of clinical case discussions.
- Analysis of diagnostic and therapeutic strategies.
Main Results:
- The primary therapeutic goal is maternal salvage, with efforts to preserve pregnancy and reduce fetal toxicity.
- Standard treatments used outside of pregnancy are often applicable, especially in later trimesters.
Conclusions:
- Maternal-fetal consensus in managing hematological cancers during pregnancy prioritizes mother and fetus.
- Further research is essential for evidence-based guidelines and improved outcomes.
