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Related Concept Videos

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Author Spotlight: Insights into Remotely Supervised Neuromodulation Procedure for Phantom Limb Pain
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Remote ischemic conditioning for stroke: clinical data, challenges, and future directions.

Wenbo Zhao1, Sijie Li2, Changhong Ren2

  • 1Department of Neurology Xuanwu Hospital Capital Medical University Beijing China.

Annals of Clinical and Translational Neurology
|January 19, 2019
PubMed
Summary
This summary is machine-generated.

Remote ischemic conditioning (RIC) shows promise for managing cerebrovascular diseases, improving outcomes in stroke patients. Further research is needed to optimize protocols and understand mechanisms for wider clinical adoption.

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Area of Science:

  • Neurology
  • Cardiovascular Medicine
  • Regenerative Medicine

Background:

  • Stroke management remains suboptimal, necessitating novel therapeutic strategies.
  • Remote ischemic conditioning (RIC) is a noninvasive intervention with potential benefits for cerebrovascular diseases.
  • RIC has demonstrated safety and tolerability in various patient populations.

Purpose of the Study:

  • To review recent clinical advances in remote ischemic conditioning for stroke management.
  • To identify challenges hindering the clinical implementation of RIC.
  • To outline future research directions for RIC in cerebrovascular diseases.

Main Methods:

  • Review of clinical studies on remote ischemic conditioning in stroke.
  • Analysis of RIC's safety, tolerability, and efficacy in different cerebrovascular conditions.
  • Identification of knowledge gaps regarding RIC protocols and biomarkers.

Main Results:

  • RIC is well-tolerated in acute ischemic stroke and subarachnoid hemorrhage patients.
  • Long-term RIC may reduce recurrent events and improve perfusion in intracranial atherosclerosis.
  • RIC may slow cognitive decline in small vessel disease and reduce lesions in carotid stenosis stenting.

Conclusions:

  • Remote ischemic conditioning presents a promising adjunctive therapy for cerebrovascular diseases.
  • Optimal RIC protocols, underlying mechanisms, and reliable biomarkers require further investigation.
  • Addressing current dilemmas is crucial for integrating RIC into routine clinical practice.