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Updated: Jan 30, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Chronic Chikungunya Virus Disease.

Mary K McCarthy¹, Bennett J J Davenport¹, Thomas E Morrison²

¹Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.

Current Topics in Microbiology and Immunology

|January 19, 2019

Summary

Chikungunya virus (CHIKV) causes long-lasting joint pain. Understanding chronic CHIKV disease mechanisms is crucial due to the lack of specific treatments and its global spread.

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Area of Science:

Virology
Immunology
Epidemiology

Background:

Chikungunya virus (CHIKV) is a mosquito-borne alphavirus causing widespread epidemics.
CHIKV infection frequently leads to persistent, debilitating arthralgia and arthritis.
Current treatment for chronic CHIKV disease relies solely on supportive care.

Purpose of the Study:

To investigate the mechanisms underlying the development and persistence of chronic Chikungunya disease.
To identify factors contributing to CHIKV-induced autoimmunity and viral persistence in joints.

Main Methods:

Review of existing literature on CHIKV pathogenesis.
Analysis of data from animal models and limited human case studies.

Main Results:

Chronic CHIKV disease may result from induced autoimmunity.
Viral persistence in joint-associated tissues is a potential factor in chronicity.
Risk factors and immunological responses are implicated in chronic disease development.

Conclusions:

Further research is essential to understand chronic CHIKV disease.
Developing CHIKV-specific vaccines or therapeutics is a priority.
Precise understanding of chronic CHIKV disease pathogenesis is needed for effective interventions.